• Meglitinides are used in the treatment of diabetes type 2
  • Drug names: Repaglinide (Prandin), Nateglinide (Starlix)
  • Binds to ATP sensitive potassium channels in Beta cells to increase insulin release
  • Meglitinides are structurally different from Sulfonylureas
  • Lowers A1C 0.5-1%
  • Plasma levels of insulin peak 30-60 min after each dose
  • Quick onset & short duration
  • Excreted in urine
  • Good drugs for patients that skip meals
  • Very expensive
  • Patient must take with meals
  • Use with caution in patients with severe liver disease



Common Side Effects

  • Hypoglycemia
  • Weight gain



Edmunds, M. W., & Mayhew, M. S. (2014). Pharmacology for the primary care provider (4th ed.). St. Louis, MO: Elsevier Mosby.

Harvey, R. A., Clark, M. A., Finkel, R., Rey, J. A., & Whalen, K. (2012). Pharmacology (5th ed.). Baltimore, MD: Lippincott.