Drugs Used To Treat Tuberculosis


Drugs Used To Treat Tuberculosis 


Drugs used to treat Tuberculosis

  • TB is always treated with 2 or more drugs
  • Combination therapy is essential for treating TB


INH (Isoniazid)

  • Ist Line of treatment for TB
  • Can elevate LFT, so monitor LFTs in patients with decreased liver function
  • Patients should not drink ETOH
  • Peripheral neuropathy is the most common adverse reaction, so administer Pyridoxine (B6) to minimize this side effect
  • May increase Phenytoin levels & cause toxicity
  • May be administered to pregnant women



  • Typically used for the first 2 months of therapy
  • Hepatitis, Hepatoxicity & Hyperuricemia (Gout) are the common side effects




  • Used in initial treatment of TB if the INH-resistant TB is greater than 4%
  • Optic neuritis, impaired red-green color discrimination, hyperuricemia (Gout) & hepatotoxicity are the common side effects
  • Not usually administered to infants & young children because they are not aware of color changes


Rifampin (RIF)

  • Broad spectrum antibiotic
  • Generally well tolerated
  • Can cause a harmless orange-red coloring or urine, sweat, saliva & tears (can ruin contact lenses)
  • Can be hepatotoxic
  • Can reduce the effectiveness of Coumadin & anti-HIV drugs
  • Not recommended to use alone in the treatment of TB because resistance can happen
  • Learn more about signs, symptoms, & treatment for tuberculosis